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KMID : 0604520050310030245
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Journal of the Society of Cosmetic Scientists of Korea
2005 Volume.31 No. 3 p.245 ~ p.251
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Evaluation of Phototoxicity for Cosmetics and Alternative Method
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Lee Jong-Kwon
Sin Ji-Soon
Kim Jin-Ho
Eom Joon-Ho
Kim Hyung-Soo
Park Kui-Lea
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Abstract
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Safety is one of the key issue in the regulation of cosmetics. Cosmetic Act deals with it in Korea. The guidance for the testing cosmetic ingredients and their safety evaluation are prepared by Korea Food and Drug Administration. Ultraviolet radiation could Induce skin damage, edema, erythema, photoaging, immune dysfunction and skin cancer. Ultraviolet radiation is classified as Group 2A(probably carcinogenic to humans) by International Agenry for Reaserch on Cancer(IARC). The in vitro methodologies for evaluating the toxic potential of ingredients reported in the literature have not yet been sufficiently validated for use in areas other than the study for mutagenicity/genotoxicity, for pre-screening for severe irritancy, for screening of phototoxicity and for evaluating the percutaneous absorption. The 3T3 neutral red uptake photoxicity test (3T3 NRU PT) was accepted as OECD toxicity guideline in 2002. The 3T3 NRU PT is an in vitro method based on a comparison of the cytotoxicitv of a chemical when tested in the presence and in the absence of exposure to a non-cytotoxic dose of UVA/visible light.
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KEYWORD
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ultraviolet irradiation, safety, 3T3 NRU PT
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